A new study has been published about how the brain cleans itself of waste products. The brain, like every other body organ, produces waste products. Among those waste products is a protein called amyloid-beta, which is a key component in the plaque that builds up in the brains of individuals with Alzheimer’s disease. Researchers noted that levels of amyloid-beta are higher during wakefulness than during sleep, and designed a study to learn more about why the protein levels change so much.
The study concludes that essentially the brain “cleans” itself during sleep by contracting the size of brain cells and pumping cerebral spinal fluid through the resulting spaces, flushing waste into the circulatory system, and eventually the liver. The lead author, Dr. Maiken Nedergaard, explains that “the brain has different functional states when asleep and when awake. In fact, the restorative nature of sleep appears to be the result of the active clearance of the by-products of neural activity that accumulate during wakefulness.” The studies performed thus far have been on the brains of mice.
This research may indicate a direction for future Alzheimer’s research. If scientists can learn more about the timing and mechanism of the brain’s own cleaning system, they may better understand why the amyloid-beta protein builds up in Alzheimer’s patients, and how that might be prevented. The research may also point the way for further research into Parkinson’s disease and Lewy Body dementia. More information may be found here and here.
Recent Comments